Internship | Risk Assessment and Toxicology
Zeist, NL
5 dagen geleden

What will you be doing?

Within the Technology cluster Risk Assessment and Toxicology (TC RATO), we are addressing the hazard and risk assessment of chemicals and nanomaterials.

  • In addition, we develop and use bioinformatics and in silico approaches together with toxicological knowledge to e.g. : support chemical grouping towards toxicological endpoints;
  • model adverse outcome pathways; and predict the safety of new chemicals and of new drug targets. Also, we participate in various research programs on alternatives to animal testing and the exposome.

    The exposome is a new concept within risk assessment and is defined as all exposures (external and internal) from a person from conception until death.

    The exposome, encompasses all non-genetic risk factors experienced during a person’s life (external exposome) and its relation to biological exposure and responses inside the human body (internal exposome).

    Within TC RATO, we focus on the application of the internal exposome primarily within the occupational setting, to reduce occupational exposures and diseases / adverse health effects.

    To support our activities, we are continuously looking for students interested in an internship for :

  • New approach methodologies for hazard and risk assessment to replace animal tests.
  • Adopting novel data types (omics, computational chemistry, biological assay data to support read across) in hazard assessment.
  • Quantitative linking of external exposure models to internal exposure models and health effects, via PBK modelling.
  • Proposing and modelling adverse outcome pathways, to link exposure to ultimate health effects, via machine learning of literature and systems biology modelling.
  • Omics and bioinformatics data analysis for biomarker discovery of internal exposure and early health effects.
  • You may also collaborate with the Technology Cluster modelling and statistics group, which delivers the computational sciences to support our activities and / or Technology Cluster Exposure Assessment and Risk Management which delivers the external exposome / exposure expertise needed to link exposure to hazards / health effects.

    Together, we offer training possibilities in hazard assessment and toxicology, systems toxicology, toxicogenomics, toxicoinformatics, bioinformatics, PBPK modelling, computational chemistry, computational drug target safety assessment, textmining, epidemiology, exposure assessment and modelling, life science databases, occupational hygiene, safe by design concepts, specific expertise on industrial chemicals, asbestos, endotoxins, food allergens and immunology, and statistics.

    What do we require of you?

  • You are a Master’s student in life sciences, with a passion for toxicology and / or risk assessment and / or affinity or interest in learning applied bioinformatics and / or computational biosciences
  • You enjoy being part of a multi-disciplinary team, but can also work independently.
  • Good communication skills.
  • What can you expect of your work situation?

    TNO is an independent research organization whose expertise and research make an important contribution to the competitiveness of companies and organizations, to the economy and to the quality of society as a whole.

    Innovation with purpose is what TNO stands for. With 3000 people we develop knowledge with a focus on practical application.

    We aim to create new products that make life more pleasant and valuable and help companies innovate, and to find creative answers to the questions posed by society.

    We work for a variety of customers : governments, the small and medium-sized enterprises (SME) sector, large companies, service providers and non-

    governmental organizations. We work together on new knowledge, better products and clear recommendations for policy and processes.

    In everything we do, impact is the key.

    What can TNO offer you?

    You want to work on the precursor of your career; a work placement gives you an opportunity to take a good look at your prospective future employer.

    TNO goes a step further. It’s not just looking that interests us; you and your knowledge are essential to our innovation.

    That’s why we attach a great deal of value to your personal and professional development. You will, of course, be properly supervised during your work placement and be given the scope for you to get the best out of yourself.

    Naturally, we provide suitable work placement compensation.

    Has this vacancy sparked your interest?

    Then please feel free to apply on this vacancy! For further questions don’t hesitate to contact us.

    Contact : Rob Stierum

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