Postdoctoral Researcher for cryo-EM studies of large protein complexes involved in cellular immunity (1.0 FTE)
Universiteit Utrecht
Utrecht, NL
3 dagen geleden

Functie

The Structural Biochemistry group of Professor Piet Gros has a long-standing track record at the frontiers of structural biology focusing on elucidating the molecular mechanisms that underlie biological processes with a major emphasis on human plasma-proteins and cell-surface receptors.

The lab has an internationally strong reputation in uncovering the molecular mechanisms that underpin the complement system.

We combine protein crystallography, cryo-electron microscopy, light microscopy, biochemical and biophysical assays to get a detailed picture of the molecular interactions that enable the complement system to discriminate between healthy self-cells and pathogens or dying / malignant cells.

We currently offer the opportunity for a postdoctoral Researcher to join forces with us on an ERC funded project that investigates the correlation between levels of organisation within the membrane and complement efficacy.

Most of the interactions we are looking into for this project are in the high nM to mM range and involve large flexible multi-domain proteins.

So, the challenge for you will be to find conditions / tricks that capture the complex of interest in a state that enables detailed structural analyses.

Prinicipal tasks and responsibilities :

  • deliver high quality protein samples for structural analyses;
  • collect and analyse cryo-EM data;
  • structure determination, atomic model building and validation;
  • function as a go-to for PhDs and Postdocs in the group for expert advice on all aspects of cryo-EM sample preparation, data collection and analyses;
  • communicate you research findings within the group and to the larger scientific community.
  • Profiel

    We seek a highly motivated individual with the ability to run their project independently, but who also likes to collaborate with and advice other members of our team.

    Required knowledge / skills / abilities :

  • a PhD in structural biology or a closely related field;
  • proven experience in cryo-EM;
  • purification and analysis of protein complexes;
  • excellent oral and written skills in English.
  • Optional skills / abilities that are considered an advantage :

  • protein crystallography;
  • Cryo-ET;
  • molecular biology;
  • handling of membrane proteins.
  • Aanbod

  • a position for two years with the possibility of an extension to a maximum of four years;
  • a full-time gross salary ranging from €2,839 to €4,474 in scale 10 of the Collective Labour Agreement Dutch Universities (cao);
  • 8% holiday bonus and 8.3% end-of-year bonus;
  • a pension scheme, partially paid parental leave, and based on the Collective Labour Agreement Dutch Universities.
  • In addition to the employment conditions laid down in the cao for Dutch Universities, Utrecht University has a number of its own arrangements.

    For example, there are agreements on professional development, leave arrangements and sports. We also give you the opportunity to expand your terms of employment yourself via the Employment Conditions Selection Model.

    This is how we like to encourage you to continue to grow.

    More information about working at the Faculty of Science can be found .

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