The Structural Biochemistry group of Professor Piet Gros has a long-standing track record at the frontiers of structural biology focusing on elucidating the molecular mechanisms that underlie biological processes with a major emphasis on human plasma-proteins and cell-surface receptors.
The lab has an internationally strong reputation in uncovering the molecular mechanisms that underpin the complement system.
We combine protein crystallography, cryo-electron microscopy, light microscopy, biochemical and biophysical assays to get a detailed picture of the molecular interactions that enable the complement system to discriminate between healthy self-cells and pathogens or dying / malignant cells.
We currently offer the opportunity for a postdoctoral Researcher to join forces with us on an ERC funded project that investigates the correlation between levels of organisation within the membrane and complement efficacy.
Most of the interactions we are looking into for this project are in the high nM to mM range and involve large flexible multi-domain proteins.
So, the challenge for you will be to find conditions / tricks that capture the complex of interest in a state that enables detailed structural analyses.
Prinicipal tasks and responsibilities :
We seek a highly motivated individual with the ability to run their project independently, but who also likes to collaborate with and advice other members of our team.
Required knowledge / skills / abilities :
Optional skills / abilities that are considered an advantage :
In addition to the employment conditions laid down in the cao for Dutch Universities, Utrecht University has a number of its own arrangements.
For example, there are agreements on professional development, leave arrangements and sports. We also give you the opportunity to expand your terms of employment yourself via the Employment Conditions Selection Model.
This is how we like to encourage you to continue to grow.
More information about working at the Faculty of Science can be found .