Scientist Clinical Immunology (Yacht Life Sciences)
YACHT
Leiden, NL
2 dagen geleden

Over de functie

For the Clinical Immunology department of our client, Yacht Life Sciences is looking for a Laboratory Scientist.

The main responsibility of the Laboratory Scientist is to guarantee the quality and robustness of the immunological assays to be used for the analysis of samples in clinical trials.

The Laboratory Scientist is also responsible for the scientific quality of the analysis of clinical trial samples, as well as long term life cycle of the methods he / she is the expert on.

To that effect, the Laboratory Scientist needs to consider the long-term strategies of the project and align his scientific strategy accordingly.

His / her activities must be executed, documented and reported according to Good Clinical Laboratory Practice (GCLP) quality requirements.

In specific, the laboratory scientist is responsible for designing, supervising, reviewing and documenting the experiments for assay development and validation.

He is responsible for the critical reagents in an assay, the experimental controls to guarantee assay performance, and for training operators on the scientific fundamentals of the assays which are used in the lab.

A laboratory scientist is quality-driven, he or she maintains his / her technical edge, and remains aware of the issues and potential areas of improvement in the laboratory.

Qualifications :

  • PhD in biological / medical sciences or equivalent, with strong immunology or virology background
  • At least 3 years of experience in a pharmaceutical, biotech company
  • Extensive, hands-on experience in the development to validation of serology (ELISA, VNA or other) or cell-based assays (ELISPOT, flow cytometry assays or other) according to regulatory standards.
  • Recent experience in optimizing functional assays for antibodies (antibody-dependent cell cytotoxicity, or antibody-dependent cell phagocytosis) is a plus
  • Recent experience in optimizing isolation, freezing and thawing of PBMCs is a plus
  • Affinity for data analysis and the thorough review of the data generated by others
  • Knowledge of procedures to establish comparability and bridging of critical reagents is a plus
  • Knowledge of biostatistics is a plus.
  • Experience with experimental plans using the Design of Experiment (DoE) principles is a plus
  • Excellent communication skills, fluent in English
  • Experienced in working under quality standards such as GCLP, GCP or GMP
  • Competences : The right candidate is :

    The right candidate is :

  • Quality minded and flexible
  • Able to remain calm and positive under pressure
  • A team player with soft skills, able to motivate and empower others.
  • Good planning and coordinating skills
  • Arbeidsvoorwaarden

    This concerns a secondment placement for 1 year, full-time (32 hours discussable for industry experienced candidates only).

    Longer term possibilities are anticipated.

    We will offer a competitive benefits package in line with the seniority of the position. You will become a member of a strong professional network who shares your education, ambitions and competencies.

    This will enable you to interact with your colleagues and become a member of the YACHT network, which stretches the Life Science industry.

    You will be challenged by your peers and will be able to follow courses and training via our Yacht Academy and keep your knowledge and skills up-

    to-date : boosting your career through personal and scientific growth.

    Bedrijfsinformatie

    Janssen Vaccines & Prevention, previously Crucell, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, is dedicated to bringing meaningful innovation to global health.

    Our teams focus on the discovery, development, manufacture and marketing of vaccines and antibodies to protect people worldwide from infectious diseases.

    In our organization entrepreneurial people are working in a dynamic culture in which innovation and a 'can do' state of mind are the central points.

    To strengthen our team, we are continuously looking for enthusiastic, talented people who have the ambition to develop themselves and can be of value to Janssen.

    Department :

    The Clinical Immunology department is responsible for the immunological evaluation of vaccine candidates in clinical trials.

    In close collaboration with the Biomarker group and clinical development group, the clinical immunology department executes the immuno strategies and ensures the development, and validation of the required immunological assays as well as clinical sample analysis and data reporting.

    Typical assays to determine the immunogenicity of vaccines are the antibody ELISA, T cell ELISpot, Intracellular Cytokine Staining, and virus neutralization assays.

    The clinical immunology department offers Janssen Vaccines with services in Scientific and operational excellence, with high standards of quality and compliance.

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